Solvent-aided phase separation in hydrogel towards significantly enhanced mechanoresponsive strength

Tuning PEG-DA hydrogel properties via solvent-induced phase separation (SIPS)().

Poly(ethylene glycol) diacrylate (PEG-DA) hydrogels are widely utilized to probe cell-material interactions and ultimately for a material-guided approach to tissue regeneration. In this study, PEG-DA hydrogels were fabricated via solvent-induced phase separation (SIPS) to obtain hydrogels with a broader range of tunable physical properties including morphology (e.g. porosity), swelling and modu...

Unusual behaviour induced by phase separation in hydrogel microspheres.

Hydrogel microspheres with the capability to interact with charged species such as various drugs by ion-exchange processes are useful in a variety of biomedical applications. Such systems have been developed to allow active loading of the microsphere with chemotherapeutic agents in the hospital pharmacy for subsequent locoregional therapy of tumours in the liver by drug-eluting bead chemoemboli...

Silk fibroin gelation via non-solvent induced phase separation.

Tissue engineering benefits from novel materials with precisely tunable physical, chemical and mechanical properties over a broad range. Here we report a practical approach to prepare Bombyx mori silk fibroin hydrogels using the principle of non-solvent induced phase separation (NIPS). A combination of reconstituted silk fibroin (RSF) and methanol (non-solvent), with a final concentration of 2....

Computer-aided strength calculation system

An important stage of the designing process in the machine-building industry is the optimization of the strength characteristics of a new product--one of the aims of the said optimization being the reduction of material content of machines and mechanisms. However, carrying out strength investigations via fuU-scale testing of prototypes and models calls for considerable material, labour and time...

Aided Solvent Selection and Design Framework